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This
section of Catalog describes the Nuc-Spheretm products from
Corpuscular. These proprietary materials and their methods of preparation
and using are patent pending.
The monodisperse nanosphere and microsphere
particles radionuclide-carriers are for research purposes only.
We offer various Core diameter and coating
thickness "cold" nanospheres which upon irradiation in nuclear reactor
produce highly concentrated radionuclide concentration useful for diagnostic
and therapeutic studies.
Silica surfaces are easily functionalized with
OH, NH2 and COOH groups, used to conjugate to antibodies.
NuP-Spheretm products will be sold only to customers with valid
licenses for work with radioactive materials from authorized government and
state agencies of respective countries.
Properties of
Holmium-166 radionuclide
Ebeta
(max.)=1.85 MeV
β5-
=651.9 keV (47.7% abundance) and
β6-
=694.6 keV (51.0% abundance)
Soft tissue penetration
-average 3.2 mm, depositing 0.2 keV/mm. The total equilibrium dose constants
Dnp
and Dp for
non-penetrating and penetrating radiations of 166-Ho are 0.398 g Gy Mbq-1h-1
and 0.017 g Gy
Mbq-1h-1,
respectively.
166-Ho
therapeutic radius is ~2.1 mm,
and the maximum radius is ~8.7 mm).
Half-life
of 26.808 h,
Gamma
emissions with suitable energies and abundance:
E =0.081 MeV (6.2%) and E=1.379 MeV (0.95%).
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